Surgery combined with endoscopic photodynamic therapy for simultaneous double primary early carcinomas of the esophagus and cardia: a case report
Year: 2025
Type: article
Study design: Case Report
Abstract: • This case is a primary malignant tumor of esophageal and cardia at the same time, which is relatively rare; • We adopted a combination of photodynamic therapy and surgical resection and achieved good results; • The treatment of this case can provide a new idea for individuals with this rare disease to develop clinical treatment plans. Known as double primary cancers or duplicated cancers, multiple primary cancers are the simultaneous occurrence of two or more primary malignancies with different histological type. The location and stage of every tumor determine the degree of complexity of treatment. Conventional methods pose great difficulties since a single modality is usually inadequate to reach total eradication. This paper addresses a 66-year-old male patient diagnosed with an esophageal tumor whose presence had been observed for more than one month without any particular symptoms or signs. The patient presented an unusual example of dual primary early carcinoma involving the cardia and the upper esophagus. Given single-modality techniques were insufficient for total eradication, the tumor in the upper esophagus, which was proximally to the neck, presented special difficulties for conventional treatment. We followed a thorough treatment schedule combining endoscopic photodynamic therapy with surgical resection. With no appreciable disease progression or complications noted over a 32-month follow-up period, this strategy produced good clinical results. In this case, surgical intervention and photodynamic therapy worked well, providing new ideas for treating similar clinical situations.
Authors: Zhu-Xin Chen, Hao Chen, Hong Wei, Ling Chen, Guo-Qing Shi
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,610
OpenAlex ID: W4410193222