CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target
Year: 2025
Type: article
Abstract: mRNA and activating the JNK inflammatory pathway, thereby increasing pro-inflammatory cytokines. Spatial co-localization of circITSN1 with neuronal markers and EIF4A3 underscored its neuron-specific regulatory role. These findings establish circITSN1 as a critical mediator of neuroinflammation through JNK pathway activation, positioning it as both a diagnostic biomarker and a promising therapeutic target for POCD intervention. The study bridges circRNA biology with neurocognitive pathology, offering novel insights into post-surgical cognitive impairment mechanisms.
Authors: Changteng Zhang, Xiaoyu Zhu, Rui Gao, Hai Chen, Caiyi Yan, Wangyang Liu, Lina Yang, Xianzheng Zeng, Haoran Yang, Jin Liu, Qi Li, Daqing Ma, Tao Zhu, Chan Chen
Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University, University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chongqing Normal University, Chelsea and Westminster Hospital, Imperial College London
Language: English
Topic: Circular RNAs in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,900
Awards: G3447052649, G4723593701, G8556697681
OpenAlex ID: W4410193956