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Carcinoembryonic Antigen (CEA) Elevation in Routine Screening Unveils Stage IV Lung Adenocarcinoma

Year: 2025

Type: article

Abstract: Carcinoembryonic antigen (CEA) is a tumor marker most often associated with colorectal cancer, but elevated levels may also indicate other malignancies, including lung cancer. Although not recommended as a standalone screening or diagnostic tool, persistent elevation in CEA levels may warrant further investigation. This case report describes a 71-year-old woman who was found to have progressively rising CEA levels during routine private health screening despite being asymptomatic. Initial workup, including colonoscopy, revealed no evidence of colorectal malignancy. However, further evaluation prompted by new respiratory symptoms and imaging findings led to the diagnosis of Stage IVa lung adenocarcinoma. This case underscores the importance of a comprehensive diagnostic approach in patients with unexplained tumor marker elevation. It highlights the potential role of primary care in identifying atypical presentations of serious conditions.

Source: Cureus

DOI: 10.7759/cureus.83751

Authors: Farha Munira Mohamed Kamel, Noor Azimah Muhammad, Amir Zharif Adenan

Institutions: University Kebangsaan Malaysia Medical Centre, National University of Malaysia, Universiti Teknologi MARA System, Universiti Teknologi MARA

Language: English

Topic: Lung Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410194275