Work

Intravenous calcitriol: a critical intervention for severe postoperative hypoparathyroidism when oral administration is not feasible

Year: 2025

Type: article

Abstract: Iatrogenic hypoparathyroidism is a serious complication that can arise from neck surgery, predominantly during thyroidectomy, parathyroidectomy, and laryngectomy; it can be transient or permanent, requiring lifelong treatment. Early detection and treatment are crucial to prevent severe hypocalcemia, which is potentially fatal. This case report describes a 59-year-old male with a history of well-differentiated squamous cell carcinoma of the vocal cords who developed severe postoperative hypoparathyroidism following total laryngectomy with right hemithyroidectomy. Despite initial treatment with cholecalciferol by nasogastric tube, the patient experienced recurrent severe hypocalcemia, requiring intravenous administration of calcitriol due to his inability to swallow. This case highlights the risk factors for triggering postoperative hypoparathyroidism, such as previous surgery or radiotherapy in the cervical region, underlines the importance of careful monitoring of postoperative hypoparathyroidism and proposes the use of intravenous calcitriol as an effective strategy in acute treatment when oral administration is not feasible.

Source: Exploration of Endocrine and Metabolic Diseases

DOI: 10.37349/eemd.2025.101431

Authors: Ignacio Jiménez Hernando, Laura González Fernández, Marta Pérez Noguero

Institution: Hospital General Universitario Gregorio Marañón

Language: English

Topic: Thyroid and Parathyroid Surgery

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410197201