Genetic ancestry influences gene-environment interactions with sociocultural factors: Results from the Hispanic Community Health Study/Study of Latinos

Year: 2025

Type: article

Abstract: performance decreased with increasing AME ancestry. After stratification, PGS-age-at-immigration interactions remained statistically significant in some strata: Mexican background individuals born in the US (50 states/DC) (β = 1.33, p < 0.01), Dominican background individuals 6-12 years old (β = 4.38, p < 0.001), and Cuban background individuals 0-5 years old (β = 2.20, p = 0.015) relative to those ≥ 21 years old at migration. It is vital to understand populations of interest to model them appropriately and prevent possible confounding or misinterpretation. While this work focuses specifically on Hispanic/Latino groups, these lessons are relevant to other groups as we diversify work to better understand gene-environment interactions.

Source: Human Genetics and Genomics Advances

DOI: 10.1016/j.xhgg.2025.100451

Authors: Jayati Sharma, Cristin E. McArdle, Mariaelisa Graff, Christina Cordero, Martha Daviglus, Linda C. Gallo, Carmen R. Isasi, Tanika N. Kelly, Krista M. Perreira, Gregory A. Talavera, Jianwen Cai, Kari E. North, Lindsay Fernández-Rhodes, Genevieve L. Wojcik

Institutions: Johns Hopkins University, Pennsylvania State University, University of North Carolina at Chapel Hill, University of Miami, University of Illinois Chicago, San Diego State University, Albert Einstein College of Medicine

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,300

Funders: Office of Dietary Supplements, University of Miami, San Diego State University, National Institutes of Health, Albert Einstein College of Medicine, Yeshiva University, University of Illinois at Chicago, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities, NHLBI Division of Intramural Research

OpenAlex ID: W4410197533