Work

Viral blips and hidden infections: pitfalls in HIV-1 prophylaxis by broadly neutralizing antibodies

Year: 2025

Type: article

Abstract: A study published in Nature 1 by Gonelli and colleagues reveals that potent, broadly neutralizing antibodies (bNAbs) delay viremic simian immunodeficiency virus (SIV) infection in rhesus macaques but do not fully prevent subclinical infections. Despite bNAb concentrations being significantly higher than supposed protective thresholds, transient viral “blips” occurred, which suggests that bNAb prophylaxis can mask subclinical infections and has implications for the interpretation of HIV-1 prevention trials.

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-025-02230-x

Authors: Fabian Zech, Frank Kirchhoff

Institution: University Hospital Ulm

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790