Work

An atypical cause of optic neuritis: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD)

Year: 2025

Type: article

Abstract: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a novel, demyelinating disease presenting with optic neuritis, along with other central nervous pathologies. First implicated in 2007, it remains a rare disease, with a prevalence of roughly 1.3 per 1 million adults. We present a case of MOGAD in a young female presenting to our rural healthcare facility with endorsements of eye pain and blurred vision. Imaging revealed findings consistent with optic neuritis, as well as hyperintensities of her cerebrum and cervical spine. Distinguishing radiographic features from other neurological pathologies, including conus medullaris enhancement, were not present, highlighting the importance of considering the clinical picture as a whole. We aim to bring awareness to this rare disease, especially to those practitioners localized to a rural environment.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.04.048

Authors: Mark A. Colantonio, Danielle Sblendorio, Elizabeth Hart, Joshua Wiley

Institution: West Virginia University

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600