Assessing ultrasonic and optical flow velocimetry in a millifluidic device using oil-in-water emulsions as blood mimicking fluid
Year: 2025
Type: article
Abstract: Blood-mimicking fluids (BMFs) play a critical role in ultrasonic imaging and Doppler flow studies by replicating the physical and acoustic properties of blood. This study introduces a novel soybean oil-in-water emulsion as a BMF with particle size akin to red blood cells. Using a millifluidic device, we cross-validated flow profiles through both Doppler velocimetry and optical particle tracking, demonstrating compatibility with theoretical Poiseuille flow models. The millifluidic chip, fabricated via stereolithography, provided an optimized platform for dual optical and ultrasonic assessments. Results showed strong agreement between the two methods across a range of flow rates, affirming the suitability of the emulsion for velocimetry applications. Furthermore, the acoustic properties of soybean oil droplets support their potential as an echogenic and stable alternative to conventional BMFs.
Source: Micro and Nano Engineering
Institutions: Centre National de la Recherche Scientifique, Université Paris Sciences et Lettres, École Normale Supérieure - PSL, Sorbonne Université, Institut Pierre-Gilles de Gennes pour la Microfluidique, University of Valparaíso, Inserm, Laboratoire d’Imagerie Biomédicale, Delft University of Technology
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,780
Funders: École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Centre National de la Recherche Scientifique, Agencia Nacional de Investigación y Desarrollo, College of Natural Resources and Sciences, Humboldt State University, Fondo Nacional de Desarrollo Científico y Tecnológico
OpenAlex ID: W4410199091