Work

Electrochemical Detection of Caffeic Acid on Diethyl 3,4-Dihydroxythiophene-2,5-Dicarboxylate-Modified Carbon Paste Electrode: Insights from Computational Analysis

Year: 2025

Type: article

Abstract: This study presents the electrochemical detection of caffeic acid using an ester (Diethyl 3,4-dihydroxythiophene-2,5-dicarboxylate)-modified carbon paste electrode (EMCPE). Caffeic acid, a naturally occurring hydroxycinnamic acid with antioxidant properties, was investigated due to its significance in food products and its potential health benefits. The modified electrode demonstrated enhanced sensitivity and selectivity for caffeic acid detection. Voltammetric methods were applied to evaluate the electrode performance. Results indicated that EMCPE has improved electron transfer kinetics and a lower detection limit compared unmodified electrode. Detection and quantification thresholds (LOD and LOQ) were found to be 3.12×10−6 M and 1.04×10−3 M. Density functional theory used to understand the electron transfer properties of Diethyl 3,4-dihydroxythiophene-2,5-dicarboxylate. The study highlights the potential of EMCPE as a reliable and cost-effective sensor to quantify caffeic acid across different sample matrices.

Source: Electrochem

DOI: 10.3390/electrochem6020019

Authors: Surya Chethana Suresh, Gururaj Kudur Jayaprakash, Sunitha Mughalihalli Shivashankar, Rajendrachari Shashanka, Bhavana Rikhari

Institutions: Nitte Meenakshi Institute of Technology, Visvesvaraya Technological University, SR University, Dayananda Sagar University

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,207

Funder: Science and Engineering Research Board