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Recent Advances in Carbon-Centered Radical-Initiated Olefin Transformation Chemistry

Year: 2025

Type: article

Abstract: In recent years, carbon-centered radical-initiated olefin transformation reactions, including alkene Heck-type alkylation, alkene hydroalkylation, and alkene difunctionalization reactions, have attracted increasing attention and been extensively developed. This review summarizes the recent advances in carbon-centered radical-initiated olefin transformation chemistry, such as radical-mediated alkene Heck-type alkylation, alkene hydroalkylation, and radical-mediated alkene difunctionalization reactions. This area of research is divided into several sections based on the types of olefin transformation reactions and the divergent formation processes of the carbon-centered radicals. Drawing extensively on our group’s investigations, we show that efficient olefin transformation strategies have gained significant traction in synthetic chemistry due to their ability to rapidly install functional groups and enhance molecular complexity.

Source: Catalysts

DOI: 10.3390/catal15050461

Authors: Huazhan Ren, Ming Hu, Jinheng Li

Institutions: Qingdao University of Science and Technology, State Key Laboratory of Applied Organic Chemistry, Henan Normal University, Lanzhou University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,654

Funders: Henan Normal University, National Natural Science Foundation of China, Natural Science Foundation of Shandong Province