Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: Preterm delivery is a leading cause of neonatal morbidity and mortality globally, with inflammation playing a crucial role in its pathophysiology. This study aimed to evaluate the predictive value of systemic inflammatory response indices in identifying pregnant women at risk of preterm delivery. Methods: This retrospective study analyzed data from 1128 pregnant women admitted to a tertiary care hospital between 2020 and 2025. Patients were classified into two groups: preterm delivery (n = 528) and term delivery (n = 600). Demographic characteristics, obstetric history, neonatal outcomes, and inflammatory indices were compared. Results: The preterm delivery group showed a significantly higher systemic inflammatory response index (SIRI) (p < 0.001), systemic immune-inflammation index (SII) (p < 0.001), neutrophil/lymphocyte ratio (NLR) (p < 0.001), and monocyte/lymphocyte ratio (MLR) (p < 0.001) than the term delivery group, while platelet/lymphocyte ratio (PLR) levels were significantly lower (p = 0.002). Inflammatory indices were higher in early preterm delivery cases (p < 0.001) than in middle and late preterm cases. Multivariate logistic regression identified the SIRI (p = 0.015) and NLR (p < 0.001) as independent predictors of preterm delivery, while the PLR showed an inverse association (p = 0.002). Higher inflammatory indices correlated with lower 1st and 5th minute APGAR scores (p < 0.001) and increased neonatal intensive care unit (NICU) admission rates (p < 0.001). NICU stay was prolonged in neonates born to mothers with elevated SIRI and NLR levels (p < 0.001). Conclusions: Integrating these inflammatory indices into obstetric risk assessment may enhance early detection and intervention strategies, potentially improving maternal and neonatal prognosis.
Source: Diagnostics
Author: Samet Kırat
Institution: Kafkas University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,137
OpenAlex ID: W4410211645