Year: 2025
Type: article
Abstract: A silver(I) triflate-catalyzed post-Ugi assembly of novel pyrazolo[1,5- a ][1,4]diazepine scaffolds is reported offering high yields (up to 98%) under mild conditions. The synthetic sequence involves the Ugi four-component reaction (U4CR) of pyrazole-3-carbaldehydes, primary amines, 3-substituted propiolic acids, and isocyanides, followed by a silver(I) triflate-catalyzed intramolecular heteroannulation of the resulting pyrazole-tethered propargylamides occurring in a 7- endo - dig fashion. The approach is scalable and tolerates a diverse range of substitution patterns.
DOI: 10.3762/bjoc.21.74
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4410212073