Work

Sixteen weeks of high-speed treadmill running is insufficient to induce Achilles tendinopathy in a rat model

Year: 2025

Type: article

Abstract: We demonstrated that 16 wk of high-speed treadmill running did not induce structural, functional, or mechanical changes consistent with Achilles tendinopathy in the rat. These findings underscore the importance of exploring alternative approaches to generating reliable and clinically relevant animal models of Achilles tendinopathy.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00186.2025

Authors: Snehal S. Shetye, Margaret K. Tamburro, Ashley K. Fung, Thomas P. Leahy, Madison N. Magee, Harina A. Raja, Stephanie N. Weiss, Courtney A. Nuss, Daniel C. Farber, Louis J. Soslowsky

Institution: University of Pennsylvania

Language: English

Topic: Tendon Structure and Treatment

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G2429945169, G3807237286, Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application), Achilles Tendinopathy Center of Research Translation

OpenAlex ID: W4410212188

FWCI: 3.674

Cites: 58

Cited by: 4

Related to: 10