Work

In Vivo Study of GFT-505 Selenium-Substituted Derivatives for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis

Year: 2025

Type: article

Abstract: Metabolic dysfunction-associated steatohepatitis(MASH) is a common liver disease worldwide and can develop into liver cirrhosis and liver cancer.Current treatment is limited, and the only drug Rezdiffra has limited effects.GFT-505 performed well as a PPAR agonist in stage II, but not as expected in stage III.We replaced the sulfur atom of GFT-505 with selenium to obtain compound 4c.Study evaluating the effect of 4c on the MASH mouse model induced by MCD.The results showed that 4c improved MASH through multi-target synergy and reduced TG and ALT better than GFT-505.This finding provides a theoretical basis and new ideas for the development of novel multi-target anti-MASH drugs.

Source: Research Review

DOI: 10.52845/cs/2025-5-3-4

Author: Jiawen Wang

Institutions: Tianjin University of Science and Technology, State Key Laboratory of Food Nutrition and Safety

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410212238

FWCI:

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