Work

Urinary exosomes exacerbate diabetic kidney disease by promoting NLRP3 inflammasome activation via the microRNA-516b-5p/SIRT3/AMPK pathway

Year: 2025

Type: article

Abstract: Urinary exosomal miR-516b-5p plays a key role in diabetic kidney disease (DKD) by promoting inflammatory response and NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation through the SIRT3/AMPK pathway.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00527.2024

Authors: Haiying Zhang, Yubo Jiang, Jun Song, Shaoqing Wang, Jianhong Lu, Fuxin Wei, Xiu Li

Institutions: Chengdu Medical College, First Affiliated Hospital of Chengdu Medical College

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Department of Science and Technology of Sichuan Province, Natural Science Foundation of Sichuan Province

Awards: G597049667, G657361453

OpenAlex ID: W4410215471

FWCI: 2.35

Cites: 33

Cited by: 9

Related to: 10