Year: 2025
Type: article
Abstract: Maduramicin is prohibited in ruminant feed due to its high toxicity. The aim of this study is to describe a case of maduramicin poisoning caused by industrial cross‐contamination of anionic salts in prepartum dairy cattle. The clinical signs observed included anorexia, depression, nasal discharge, salivation, reddish urine and haematochezia. Morbidity was 100%, and lethality was 85%. Macroscopic lesions were consistent with congestive heart failure, characterised by hydrothorax and pulmonary oedema. Histopathology showed coagulative necrosis in cardiomyocytes and pulmonary oedema. The CPK levels ranged from 26,386 to 53,398 U/L, while the LDH and AST levels were 18,462 and 3610 U/L, respectively. The concentration of maduramicin in anionic salts was 7000 ppm. The combination of epidemiological, clinical, anatomopathological and analytical evidence allowed us to conclude that the mortality was a result of maduramicin consumption from the anionic salts.
Source: Veterinary Record Case Reports
DOI: 10.1002/vrc2.70077
Authors: Di Paolo Leandro Adrián, Sosa Pedro Sebastian, Ancinas María Dolores, Muñoz Alejandro, Travería Gabriel Eduardo
Institution: Universidad Nacional de La Plata
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $1,480
Funder: Universidad Nacional de La Plata
OpenAlex ID: W4410215917