Work

Ubiquitin-SUMO tag-team wrestles acute promyelocytic leukemia

Year: 2025

Type: article

Abstract: In this issue, Jaffray and colleagues (https://doi.org/10.1083/jcb.202407133) detail the molecular machinery required to degrade the oncogene PML in response to arsenic treatment. Different posttranslational modifiers team up: ubiquitin, SUMO1, and -2/3, linked by the SUMO-targeted ubiquitin ligases TOPORS and RNF4.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202504010

Author: Alfred C.O. Vertegaal

Institution: Leiden University Medical Center

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4410217331