Work

Rosai-Dorfman Disease Case Report

Year: 2025

Type: article

Abstract: Introduction: Rosai-Dorfman disease (RDD) is a rare histiocytic disorder that is characterized by the accumulation of histiocytes in various tissues, most commonly the lymph nodes. Cutaneous RDD is a rare presentation, accounting for less than 10% of all RDD cases. Case Presentation: An 18-year-old female presented for the first time with a dome-like lesion over an indurated plaque. Both lesions were biopsied, and findings suggested RDD. The patient was referred to an oncologist with a subsequent positron emission tomography scan showing hypermetabolic subcutaneous uptake on bilateral thighs and bilateral lumbar lesions, likely corresponding to the patient's biopsy-proven histiocytosis in addition to a diffuse increased tracer uptake in the thoracic aorta and atria. Conclusion: A high degree of suspicion is necessary when dermatologists notice two different morphologies present in proximity to rule out a single pathological process. This case is unique because of the rarity of the condition as well as the clinical presentation of two different morphologies of an indurated plaque and a dome-like lesion on the same area of the body.

Source: Case Reports in Dermatology

DOI: 10.1159/000546278

Authors: Naif M. Altamimi, Vivian Li, Hershel Kahn, Gibran Shaikh

Institutions: University of Ha'il, Lake Erie College of Osteopathic Medicine, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Histiocytic Disorders and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030