Work

Chronic succinate exposure does not cause liver injury

Year: 2025

Type: article

Abstract: Succinate has been associated with hepatotoxicity in cellular, animal, and human models, including metabolic syndrome. This is the first report that evaluates the liver integrity effect of chronically elevated systemic succinate as measured by mass spectrometry. We show that liver histopathology, functional readouts, and high-resolution respirometry show normal levels following chronic succinate exposure. Thus, this research challenges the prevalent concept that succinate elevation is injurious to the liver in vivo.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00129.2025

Authors: Joseph Balnis, Emily L. Jackson, Lisa A. Drake, Catherine E. Vincent, Hwajeong Lee, Harold A. Singer, Ariel Jaitovich

Institutions: Albany Medical College, Albany Medical Center Hospital, Institute for Clinical Pharmacodynamics (United States)

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, NHLBI Division of Intramural Research

Awards: G1080908210, G1200642561, G2804477022, G321157450, G5352885903, Calcium/ Calmodulin Activated Kinases in Smooth Muscle, G5817219198, G6116468102, G6402920775

OpenAlex ID: W4410218272

FWCI: 3.429

Cites: 39

Cited by: 4

Related to: 10