Work

Enhancing Recruitment Rate and Heterogeneity in the TrialNet Pathway to Prevention Study: Insights from a Single Center Experience

Year: 2025

Type: preprint

Abstract: Studies to predict and prevent type 1 diabetes (T1D) are limited by small numbers and lack of participation from all affected populations. We compared TrialNet Pathway to Prevention recruitments at one pediatric center 12 months before (June 2021-May 2022, n=15) and after (June 2022-May 2023, n=319) implementation of knowledge-based interventions aimed at clinicians and participants to increase recruitment. Recruitment increased by over 20-fold, with higher enrollment for all reported races and ethnicities although the overall population was largely non-Hispanic and White. Effective interventions are still needed to overcome recruitment barriers in order to ensure that the enrolled population reflects the overall affected population.

Source: medRxiv

DOI: 10.1101/2025.05.08.25327263

Authors: Alejandro F. Siller, Serife Uysal, Rebecca Schneider Aguirre, Tracy Patel, Ananta Addala, Laura M. Jacobsen, Heba M Ismail, Maria J. Redondo, Mustafa Tosur

Institutions: Baylor College of Medicine, Stanford University, University of Florida, Indiana University, Texas Children's Hospital

Language: English

Topic: Ethics in Clinical Research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: green

OpenAlex ID: W4410219660

Cites: 8

Cited by:

Related to: 10