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Ceftriaxone-Induced Thrombocytopenia: A Case Report on a Rare Medical Condition

Year: 2025

Type: article

Abstract: We present a case of antibody-confirmed drug-induced thrombocytopenia (DITP) caused by ceftriaxone. DITP is a rare but potentially life-threatening cause of isolated thrombocytopenia in the inpatient setting, often leading to critically low platelet levels. The underlying mechanism is believed to be an immune-mediated response, where drug-dependent antibodies bind to glycoproteins on the platelet membrane in the presence of the offending drug, resulting in platelet destruction and thrombocytopenia. We describe a case of ceftriaxone-induced thrombocytopenia in a patient being treated for aspiration pneumonia complicated by sepsis. To the best of our knowledge, only eight similar cases have been reported in the literature.

Source: Cureus

DOI: 10.7759/cureus.83811

Authors: Badri Aryal, Audrey Simmons, Giri Ekkurthi, Bibechana Panthi, Oscar Ruben Pena-Vizcarra

Institutions: John H. Stroger, Jr. Hospital of Cook County, Rosalind Franklin University of Medicine and Science, Lumbini Medical College

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410219694