Work

The potential of polyphenols and polyphenol-rich extracts against human papillomavirus infections and associated cancers

Year: 2025

Type: article

Abstract: Human papillomavirus (HPV) infection is a prevalent sexually transmitted infection worldwide, that can affect the skin, genital area, and throat. HPV can lead to various cancers, including cervical and anogenital cancers. Although HPV vaccination is a preventive measure, its availability remains limited, particularly in low- and middle-income countries, leading to increased demand for alternative preventive and therapeutic options. Recent research has highlighted the potential of dietary polyphenols to reduce HPV infections and related malignancies. Polyphenolic-rich foods may inhibit cancer cell proliferation through mechanisms such as stimulating immune responses, reducing DNA synthesis, inducing apoptosis, and inhibiting angiogenesis. This study reviews the therapeutic properties of polyphenols and their mechanisms in preventing HPV infection and related cancers. Future studies should focus on the clinical application of polyphenols in diverse populations and their efficacy as complementary treatments for HPV-related malignancies.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2025.106873

Authors: Atefeh Arab, Fatemeh Amini, Aida Iraji, Mohammad Hashem Hashempur

Institutions: Mashhad University of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Shiraz University of Medical Sciences

Language: English

Topic: Phytochemicals and Antioxidant Activities

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800