Work

Synthesis and Evaluation of Pseudo glucosinolates Releasing Isothiocyanates in the Presence of Azoreductases

Year: 2025

Type: article

Abstract: Naturally occurring isothiocyanates (ITCs) display multiple interesting bioactivities, but their medicinal exploitation is very limited as ITCs are non-druglike compounds with problematic pharmacokinetic properties. The concept of pseudoglucosinolates provides a novel prodrug approach for the release of ITCs which can be adjusted to different triggers such as enzymatic and chemical microenvironments. Herein, the first adaptation of this concept toward the release of ITCs in the presence of azoreductases within a turn-on fluorescence probe is reported and its applicability in covalent protein labeling is underlined.

Source: ChemBioChem

DOI: 10.1002/cbic.202500152

Authors: Aishi Chakrabarti, Charity S. G. Ganskow, Mervic D. Kagho, Claire. C. Jimidar, Lorenz Wiese, Neslihan Beyazit, Ulrike Beutling, Margarita Seeger, Silvana Smits, Stella Nyström, Anne Farewell, Anett Schallmey, Mark Brönstrup, Philipp Klahn

Institutions: University of Gothenburg, Technische Universität Braunschweig, Helmholtz Centre for Infection Research

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

Funders: Max-Buchner-Forschungsstiftung, Fonds der Chemischen Industrie, Deutsche Forschungsgemeinschaft, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, Technische Universität Braunschweig, Göteborgs Universitet, Science for Life Laboratory, Niedersächsisches Ministerium für Wissenschaft und Kultur, Leibniz-Gemeinschaft

Awards: G1513386522, G2275666846, G339893303

OpenAlex ID: W4410220539

FWCI: 0.589

Cites: 55

Cited by: 2

Related to: 10