Year: 2025
Type: editorial
Abstract: -Methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels that play a critical role in synaptic plasticity, learning, and memory in the central nervous system (CNS). These receptors assemble into functionally diverse complexes composed of GluN1, GluN2, and GluN3 subunits. Among them, GluN1/GluN2A is expressed predominantly in adult brain, and its dysfunction has been implicated in various neuropathological conditions. Recent advances have identified several GluN2A-targeted agents, including highly selective negative allosteric modulators (NAMs). Structure-activity relationship (SAR) studies of existing agents have provided valuable insights into structural modifications that enhance pharmacological properties, offering promising avenues for therapeutic development.
Source: ACS Medicinal Chemistry Letters
Authors: Yinlong Li, Hongjie Yuan, Steven H. Liang
Institution: Emory University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Emory University, Georgia Clinical and Translational Science Alliance, Royal Society, National Institutes of Health, Directorate for Biological Sciences, School of Medicine, Emory University, National Institute on Aging, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W4410224445