Work

Mediation of the Association Between APOE ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study

Year: 2025

Type: article

Abstract: BACKGROUND AND OBJECTIVES: 4 on cognition and dementia through different disease markers on structural in vivo brain imaging. METHODS: 4 carriership on cognition and dementia into natural direct and indirect effects and corresponding percentage mediated. We adjusted models for potential confounders. RESULTS: value = 0.04). DISCUSSION: ε4 on cognition is mediated by structural brain imaging markers, driven mainly by cerebral microbleeds. For dementia, mediation by these markers was limited.

Source: Neurology

DOI: 10.1212/wnl.0000000000213679

Authors: Jacqueline J. Claus, Mathijs T. Rosbergen, Jeremy A. Labrecque, Meike W. Vernooij, Frank J. Wolters, Mohammad Arfan Ikram

Institution: Erasmus MC

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: ZonMw