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Mental Health Impact in Peyronie’s Disease: the Mind-pd Study

Year: 2025

Type: article

Abstract: Objectives Peyronie’s disease (PD) has been linked to depression, however, findings vary. We aimed to assess the prevalence, severity and predictors of depressive symptoms in men with PD. Methods PD patients were recruited from two andrological outpatient clinics. Data were collected through a questionnaire including the Peyronie’s Disease Questionnaire (PDQ), Erection Hardness Score (EHS), and the Major Depression Inventory (MDI). Additional data came from electronic medical records. The primary outcome was the prevalence of depression, defined as an MDI score of 25 or higher. Secondary outcomes included MDI scores and predictors of depression. Univariate analyses explored associations between MDI scores and age, BMI, Charlson Comorbidity Index, relationship status, sexual activity, EHS, PD phase, and symptom duration. Significant predictors from univariate analyses were included in multivariate analyses. Results Of 77 invited PD patients, 50 (65%) participated. Their median age was 60 years (range 35–76) and the median BMI was 26.2 (range 20–32.7). 48 were in relationships, and 34 were sexually active. PD symptoms had been present between less than a month to over 2 years. 23 men were in the stable phase, and 27 in the active phase. The median penile curvature was 45 degrees (range 0–80). The median PDQ score was 21 (range 1–52), and the median MDI score was 6.5 (range 0–32). One man met the study definition of depression. Univariate analysis revealed that only younger age (p = 0.0001) and higher PDQ pain domain scores (p = 0.048) were associated with higher MDI scores. On robust multiple regression analysis, higher pain scores were associated with increased MDI scores (coefficient = 0.3512, 95% CI: 0.0650 to 0.6374, p = 0.0162), while older age was associated with lower MDI scores (coefficient = -0.2521, 95% CI: -0.4238 to -0.0807, p = 0.0039). Conclusions We found no link between PD and depression, with only one participant meeting the MDI threshold. Younger age and pain were associated with higher MDI scores, but the clinical relevance is limited, as most scores fell within the normal range. Conflicts of Interest None.

Source: The Journal of Sexual Medicine

DOI: 10.1093/jsxmed/qdaf077.079