Work

Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D

Year: 2025

Type: article

Abstract: nascent adhesions, supported by Arp2/3-vinculin interactions, is essential to form mechanically stable links between fibrous extracellular matrix and actin in 3D. This highlights how experiments on stiff, planar substrates may conceal actin architectural features that are essential for morphogenesis in 3D.

Source: iScience

DOI: 10.1016/j.isci.2025.112623

Authors: Tadamoto Isogai, Kevin M. Dean, Philippe Roudot, Evgenia V. Azarova, Kushal Bhatt, Meghan K. Driscoll, Shaina P. Royer, Nikhil Mittal, Bo-Jui Chang, Sangyoon J. Han, Reto Fiolka, Gaudenz Danuser

Institutions: The University of Texas Southwestern Medical Center, Michigan Technological University

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,240

Funders: University of Texas Southwestern Medical Center, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: Functional causality in regulating cell morphogenesis, G2207529866, G407385965, G4113858499, G428461830, G814400459, Symmetry breaking and polarization of cell in 3D environments, G9000020410, G9000128852, G9000174283, G9000270611, UT Southwestern Medical Center Simmons Comprehensive Cancer Center

OpenAlex ID: W4410236609

FWCI: 0.837

Cites: 70

Cited by: 2

Related to: 10