In situ growth of luminescent d-f MOF nanostructures on bacterial cellulose as an accessible kit for early jaundice diagnosis
Year: 2025
Type: article
Abstract: During the initial week after birth, a majority of newborns experience hyperbilirubinemia and jaundice as a result of the build-up of unconjugated Bilirubin (BR) in their bloodstream. If elevated BR levels are not adequately addressed, it could result in brain damage. Despite advancements in luminescence-based sensing technology for clinical purposes, there remains a significant demand for diagnostic devices with accurate, specific, portable, and affordable features. We present a luminescent nanopaper-based assay kit for visual recognition of BR. This novel kit comes with a smartphone readout, enabling effortless recognition of BR. To develop the kit, a new d − f heterometallic MOF {[Ce 2 Zn(pzdc) 4 (H 2 O) 6 ]·2H 2 O} n (pzdc = 2,3-pyrazinedicarboxylic acid) (CeZn-MOF) with advantageous photophysical features was grown on bacterial cellulose (BC) nanofibers to form BC@CeZn-MOF platform. The platform’s luminescence quenches in the presence of BR with a turn-off mechanism originating from Inner Filter Energy (IFE). The luminescence quenching was linearly proportional to the concentration of BR in range of 0.1 − 20 mg.dL − 1 (LOD = 0.027 mg.dL − 1 ), and recognition of small amount of BR could be attained with a smartphone camera. Furthermore, the luminescence emission of the sensing platform was recovered upon UV light (470 nm) through photo-isomerizing of BR into lumirubin as a non-PL quencher. The kit’s feasibility was confirmed through validating its practicality for detecting BR in human serum samples and its compatibility with clinical procedures. The non-poisonous nature and distinctive photophysical characteristics of platform makes it an excellent choice, easy-to-use BR recognition assay kit.
Source: Scientific Reports
Institutions: University of Tehran, Polish Academy of Sciences
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W4410237248