Year: 2025
Type: article
Study design: Observational Study
Abstract: The analysis of blood metabolites may help identify individuals at risk of having COPD and offer insights into its underlying pathophysiology. This study aimed to identify COPD-related metabolic alterations and generate a biological signature potentially useful for screening purposes. Plasma metabolomic profiles from 91 COPD patients and 91 controls were obtained using complementary semi-targeted and untargeted LC-MS approaches. Univariate analysis identified metabolites with significant differences between groups, and enrichment analysis highlighted the most affected metabolic pathways. Multivariate analysis, including ROC curve assessment and machine learning algorithms, was applied to assess the discriminatory capacity of selected metabolites. After adjustment for major potential confounders, 56 metabolites showed significant differences between COPD patients and controls. The enrichment analysis revealed that COPD-associated metabolic alterations primarily involved lipid metabolism (especially fatty acids and acylcarnitines), followed by amino acid pathways and xenobiotics. A panel of 10 metabolites, mostly related to lipid metabolism, demonstrated high discriminatory performance for COPD (ROC-AUC: 0.916; 90.1% sensitivity and 89% specificity). These findings may contribute to improving screening strategies and a better understanding of COPD-related metabolic changes. However, our findings remain exploratory and should be interpreted with caution, needing further validation and mechanistic studies.
DOI: 10.3390/ijms26104526
Authors: Carme Casadevall, Bella Agranovich, Cesar Jesse Enríquez-Rodríguez, Rosa Faner, Sergi Pascual-Guàrdia, Ady Castro-Acosta, Ramon Camps-Ubach, Judith Garcia-Aymerich, Esther Barreiro, Eduard Monsó, Luis Seijo, Juan José Soler-Cataluña, Salud Santos, Germán Peces-Barba, José Luis López-Campos, Ciro Casanova, Alvar Agustí, Borja G. Cosío, Ifat Abramovich, Joaquim Gea
Institutions: Universitat Pompeu Fabra, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Centro de Investigación Biomédica en Red, Hospital del Mar Research Institute, Technion – Israel Institute of Technology, Fundació Clínic per a la Recerca Biomèdica, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Hospital Universitario 12 De Octubre, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Institute of Research and Innovation Parc Tauli, Hospital Universitario Fundación Jiménez Díaz, Clinica Universidad de Navarra, Universidad Autónoma de Madrid, Universitat de València, Hospital Arnau de Vilanova, Institut d'Investigació Biomédica de Bellvitge, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Universidad de La Laguna, Hospital Clínic de Barcelona, Health Research Institute of the Balearic Islands, Hospital Universitario Son Espases, Universitat de les Illes Balears
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: BIOMARCADORES Y PERFILES CLINICOS DIFERENCIADOS EN FASES PRECOCES DE LA ENFERMEDAS PULMONAR OBSTRUCTIVA CRÓNICA (BIOEARLY-COPD), Desarrollo pulmonar anormal vs. envejecimiento acelerado en la EPOC: una aproximación a partir del análisis de redes multinivel, G4453048528, DETERMINANTES GENETICO-AMBIENTALES DEL DESARROLLO DE LA FUNCION PULMONAR EN LA INFANCIA Y ADOLESCENCIA: CATCH-UP, G687901594, G7777157821, G8379158882, G8742353108, G8762886279, G8763915067, G9000348072
OpenAlex ID: W4410240210