Electrochemical oxidative CF 3 radical-induced lactonization and etherification of terminal and internal alkenes
Year: 2025
Type: article
Abstract: radical-promoted cyclization, synthesizing functionalized lactones and cyclic ethers from terminal and internal alkenes with good to high yields. Mechanistic insights were supported by cyclic voltammetry, radical scavenger experiments, and DFT calculations. The protocol's efficiency highlights its potential in medicinal chemistry for developing pharmacologically valuable compounds avoiding the use of rare metal electrodes.
Source: RSC Advances
DOI: 10.1039/d5ra01852h
Authors: Riccardo Grigolato, Tommaso Fantoni, Giuseppe Autuori, Matteo Lattanzi, Lucia Ferrazzano, Walter Cabri, Alessandra Tolomelli
Institution: University of Bologna
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Funder: Università di Bologna
OpenAlex ID: W4410241534