Work

Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin

Year: 2025

Type: article

Abstract: TrpRS. These findings deepen our understanding of the inhibitory mechanism of CXM and its selectivity toward bacterial TrpRSs, and thus can facilitate the design of next-generation antibiotics targeting bacterial TrpRSs.

Source: RSC Chemical Biology

DOI: 10.1039/d5cb00060b

Authors: Yichen Ren, Sili Wang, Wen Liu, Jing Wang, Pengfei Fang

Institutions: Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Science and Technology Commission of Shanghai Municipality, National Key Research and Development Program of China

Awards: G1866106579, G3600007, G3625811929, G4258152613, G4532272001, G5665190907, G6751308788, G7727370608, G8455140581

OpenAlex ID: W4410244230

FWCI: 0.255

Cites: 30

Cited by: 1

Related to: 10