Year: 2025
Type: article
Abstract: 结直肠癌(Colorectal cancer, CRC)在我国及全球范围内的发病率和死亡率均位居前列，其发病率呈不断上升趋势，严重威胁人类健康。传统抗肿瘤治疗手段易产生耐药性，积极寻找新的分子靶点对CRC的防治至关重要。热休克蛋白(Heat shock proteins, HSPs)是一个成员庞大的多肽类蛋白质家族，在细胞内广泛存在，并通过多种途径参与细胞的生理和病理过程。HSP110作为HSPs中的一员，近年研究发现，HSP110在CRC中具有双重角色及机制复杂性的特点，而其在CRC领域的文献相对分散，缺乏系统性综述。本文归纳总结了目前国内外关于HSP110与CRC相关的研究，系统阐述了HSP110在CRC中的功能及作用。我们表明，HSP110在CRC中发挥了双重作用，有望为HSP110在CRC的诊治和研究提供新的思路与帮助。Colorectal cancer (CRC) remains a leading cause of global morbidity and mortality, with a steadily increasing incidence that poses significant public health challenges. Conventional anticancer therapies often develop resistance, highlighting the critical need for novel molecular targets. Heat shock proteins (HSPs), a conserved polypeptide protein family ubiquitously expressed in cells, modulate cellular physiological and pathological processes through diverse mechanisms. Recent studies reveal that HSP110, a member of the HSP family, exhibits dual roles and complex mechanisms in CRC pathogenesis. However, existing literature remains fragmented, lacking systematic synthesis. This review comprehensively reviews current research on HSP110 in CRC and systematically delineates its functional roles. We elucidate the dual regulatory roles of HSP110 in CRC progression and propose novel perspectives for diagnostic and therapeutic strategies targeting HSP110.
Source: Advances in Clinical Medicine
Author: 瑾瑾 赵
Language: English
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4410244384