Work

Efficient constitution of a library of rotenoid analogs active against Trypanosoma cruzi from a digitalized plant extract collection

Year: 2025

Type: article

Abstract: Branching out into knowledge! We build a KG to enrich and align metabolomics datasets, revealing bioactive compounds from plant extracts. We uncover anti- T. cruzi activity of rotenoids from 4 plant species, and isolate and characterize 41 analogs.

Source: RSC Advances

DOI: 10.1039/d4ra08652j

Authors: Arnaud Gaudry, Laurence Marcourt, Marcel Kaiser, Julien Flückiger, Bruno David, Antonio Grondin, Jean-Robert Ioset, Pascal Mäser, Emerson Ferreira Queiroz, Pierre-Marie Allard, Jean-Luc Wolfender

Institutions: University of Geneva, Swiss Tropical and Public Health Institute, University of Basel, Drugs for Neglected Diseases Initiative, University of Fribourg

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: National Science Foundation, Les Laboratories Pierre Fabre, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Bundesministerium für Bildung und Forschung, Ministerie van Buitenlandse Zaken, Drugs for Neglected Diseases initiative

Awards: NMR 600MHz for metabolomics and biomarker identification for life sciences, chemical biology and medical projects at the University of Geneva, G4060900387, G5210329236, An in silico and chemo-biological approach to identify anti-infective and pro-metabolic natural products

OpenAlex ID: W4410244569

FWCI: 1.219

Cites: 56

Cited by: 2

Related to: 10