Antagonism of prostate α1A-adrenoceptors by verapamil in human prostate smooth muscle contraction
Year: 2025
Type: article
Abstract: Voiding symptoms and hypertension are common comorbidities. α1-Blockers are the first-line medication for treatment of voiding symptoms. Off-target antagonism of α1-adrenoceptors by cardiovascular drugs may add to side-effects of α1-blockers, but may also hold a potential to avoid polypharmacy. Here, we examined α1-adrenergic antagonism by the calcium channel blocker verapamil in the human prostate.
Authors: Sheng Hu, Guangyang Liu, Oluwafemi Kale, Wenbin Zhu, Yajie Xu, Patrick Keller, Philipp Weinhold, Alexander Tamalunas, Christian G. Stief, Martin Hennenberg
Institutions: LMU Klinikum, Ludwig-Maximilians-Universität München
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,750
Awards: G1837661503, G8203922244
OpenAlex ID: W4410247292