Work

Case Report: Complete recovery of a patient with occult septic shock following supranormal vasopressor and inotrope therapy informed by the novel ‘pressure field method’ for managing hemodynamics

Year: 2025

Type: article

Abstract: Complete recovery of a patient with occult septic shock and left ventricular ejection fraction of 10% was achieved following management informed by continuous measurement and visualization of the patient's 'pressure field'. The 'pressure field' visualizes mean perfusion pressure as the product of stroke volume and a beat-to-beat measure of vascular tone, termed systemic elastance. The pressure field guided the titration of inotropes and vasopressors at high doses, including norepinephrine equivalents >2.5 μg/kg/min, to restore the patient's estimated pre-morbid pressure field values. Urine output was maintained throughout with no ileus. We hypothesize that pressure field management assists in individualizing care for patients with septic shock and improves outcomes.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1552050

Authors: Stephen F. Woodford, Ruth C. Marshall

Institutions: The University of Melbourne, Austin Hospital, Austin Health

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801