Work

Association of exposure to urinary and blood heavy metals with visual disability among U.S. adults in NHANES 2013–2018

Year: 2025

Type: article

Abstract: Background: Heavy metals exposure has been widely referred to as a risk factor for human health. However, studies on the potential impact of heavy metals on visual disability are limited. Herein, this study aims to investigate the associations of urinary and blood heavy metals with visual disability in adults. Methods: A total of 4,284 eligible participants in the 2013-2018 National Health and Nutrition Examination Survey (NHANES) were enrolled in our cross-sectional study. The urinary barium (Ba), cadmium (Cd), cesium (Cs), cobalt (Co), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (Tl), tin (Sn), tungsten (Tu), and mercury (Hg) and blood Pb, Cd, and Hg were included for analysis. We used multivariate logistic regression, weighted quantile sum (WQS) regression, quantile-based gcomputation (qgcomp) regression, and Bayesian kernel machine regression (BKMR) to assess the mixed-metal effect on visual disability. The subgroup analysis was stratified by age. Results: = 0.034 and 0.018). In mixed metal effect analysis, WQS, qgcomp, and BKMR models consistently demonstrated a positive association between blood and urine metal co-exposure and visual disability. Furthermore, we found that Cd and Pb were the top-weighted metals responsible for the overall effect. However, these associations were not pronounced in the older adults. Conclusions: Our findings suggested that Cd, Pb, Sn, and Tu were identified as independent risk factors for visual disability. Furthermore, exposure to mixed metals could increase the risk of visual disability, to which Cd and Pb were the greatest contributors.

Source: Frontiers in Public Health

DOI: 10.3389/fpubh.2025.1583105