Work

3,6-Anhydrogalactal as a Single-Addition Monomer for Chain-End Functionalization of Metathesis Polymers

Year: 2025

Type: article

Abstract: Controlling the structure and reactivity of the chain-end group is a central objective in modern polymer chemistry. Here we introduce 3,6-anhydrogalactal as a single-addition monomer that enables efficient and versatile chain-end functionalization of metathesis polymers. Readily synthesized from biomass-derived galactal, 3,6-anhydrogalactal exhibits excellent single-addition reactivity, allowing precise chain-end modifications even when introduced simultaneously with the propagating monomer. Theoretical calculations provide mechanistic insights into the unique reactivities governing its single-addition behavior. Its broad functional group compatibility facilitates diverse applications, including block copolymer synthesis, polymer-polymer coupling, and bioconjugation, demonstrating significant potential for advancing polymer materials and bioconjugation strategies.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c03379

Authors: Zefeng Zhou, Quan Pham, Gavin J. Giardino, Abhishek Chatterjee, Jia Niu

Institution: Boston College

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Camille and Henry Dreyfus Foundation, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry

Awards: CryoProbe-enabled Bruker AVANCE NEO 500 MHz NMR Spectrometer, G282645812, G2965188289, G8218799065