Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges
Year: 2025
Type: review
Abstract: Gaining significant attention in recent years, starvation therapy based on the blocking nutrients supply to cancer cells via blood occlusion and metabolic interventions is a promisingly novel approach in cancer treatment. However, there are many crucial obstacles to overcome to achieve effective treatment, for example, poor-targeting delivery, cellular hypoxia, adverse effects, and ineffective monotherapy. The starvation-based multitherapy based on multifunctional nanomaterials can narrow these gaps and pave a promising way for future clinical translation. This review focuses on the progression in nanomaterials-mediated muti-therapeutic modalities based on starvation therapy in recent years and therapeutic limitations that prevent their clinical applications. Moreover, unlike previous reviews that focused on a single aspect of the field, this comprehensive review presents a broader perspective on starvation therapy by summarising advancements across its various therapeutic strategies.
Source: Cancer and Metastasis Reviews
Authors: Nam Anh Tran, Shehzahdi S. Moonshi, Alfred K. Lam, Cu Tai Lu, Cong Quang Vu, Satoshi Arai, Hang Thu Ta
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
OpenAlex ID: W4410260288