Work

Breathing Effort in Preterm Infants Comparing NIV NAVA and CPAP —A Randomised Crossover Study

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: AIM: To compare breathing effort in preterm infants during neurally adjusted ventilatory assist (NIV NAVA) and continuous positive airway pressure (CPAP). METHODS: In this randomised crossover study, preterm infants were randomised to 4 h on NIV NAVA and 4 h on CPAP during daily activity and care. Breathing effort was measured by the diaphragmatic load (Edi) as Edi peak and Edi minimum, respiratory parameters, modified Silverman Andersen index and COMFORT neo score. The parents provided feedback regarding their child's comfort and breathing. RESULTS: beyond the postextubation period were included. We found a statistically significant difference in Edi peak (mean difference -1.4% CI: -2.4 to -0.4, p = 0.010) but no significant difference in Edi minimum (-0.1, 95% CI: -0.2 to 0.1, p = 0.521) comparing NIV NAVA to CPAP. Among the 10 secondary outcomes, the respiratory rate was significantly lower on NIV NAVA (-4, 95% CI: -6 to -1, p = 0.013) and there were slightly larger clinical distress scores on CPAP. While almost all parents reported that their child seemed comfortable, not all found the infant's breathing effortless. CONCLUSION: Edi peak was significantly lower in preterm infants during NIV NAVA versus CPAP.

Source: Acta Paediatrica

DOI: 10.1111/apa.70132

Authors: Hilde Brenne, Turid Follestad, Håkon Bergseng, Laila Kristoffersen, Kristine Hermansen Grunewaldt

Institutions: St Olav's University Hospital, Norwegian University of Science and Technology

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Helse Midt-Norge, St. Olavs Hospital Universitetssykehuset i Trondheim