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OPTIMIZING EXTRACTION CONDITIONS TO ENRICH POLYPHENOL AND FLAVONOID FROM Ehretia asperula LEAF EXTRACT AND EVALUATING ITS IN VIVO HEPATOPROTECTIVE PROPERTIES

Year: 2025

Type: article

Abstract: Ehretia asperula is a medicinal plant rich in polyphenols and flavonoids, with potential bioactive properties, and is used in traditional medicines. This study aimed to extract and optimize the antioxidant activity of the extract and determine its hepatoprotective effects. The extraction conditions were optimized using the Box-Behnken method at different temperatures, ethanol concentrations, and solid-liquid ratios. Antioxidant capacity was assessed using ABTS•+, DPPH, reducing power (RP), and total antioxidant capacity (TAC) assays, and hepatoprotective efficacy was evaluated in a CCl4-induced liver injury mouse model.

Source: Mitteilungen Klosterneuburg

DOI: 10.61586/4uajl

Authors: Dai Thi Xuan Trang, Tran Chi Linh, Luu Thai Danh, Chau Thanh Tuan, Ly Huynh Lien Huong, Nguyen Trong Tuan

Institutions: Nam Can Tho University, Can Tho University, Can Tho University of Medicine and Pharmacy

Language: English

Topic: Phytochemicals and Antioxidant Activities

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4410273284

FWCI:

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