Year: 2025
Type: article
Abstract: Objective: This review investigated the origin, surface markers, and the regenerative potential of mesenchymal stem cells from the oral cavity. Background: This review addresses the regenerative potential of mesenchymal stem cells (MSCs) from the oral cavity, including the formation of dental tissues, pulp tissue, and periodontal tissues, and a whole bio-hybrid tooth composed of dentin, cementum, periodontal ligament, and alveolar bone. Teeth sequelae can be caused by cavities, trauma, or infection, leading to endodontic problems, periodontal disease, and tooth loss. Method: This work selected 67 articles revising the literature using PubMed and Google Scholar, these stem cells were separated according to their origin, surface markers, and regenerative potential. Conclusion: Although a lot of research and clinical trials have to be done to validate clinical use of this knowledge in humans, this field is vast and promising, bringing light to new therapies that can solve clinical problems and reformulate dental treatments shortly.
Authors: Marcos Fernando Xisto Braga Cavalcanti, Ícaro Gabriel Teles Pacheco De Matos, Ala Gustavo De Andrade Costa, Gianny Dominicci Batista Brito, Francesca Diomede, Durvanei Augusto Maria
Institution: Instituto Butantan
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410273460