Genotypic Distribution of Alpha-Like Proteins in Group B Streptococcus Strains Isolated in Korea: Implications for Vaccine Coverage
Year: 2025
Type: article
Abstract: BACKGROUND: genotype in domestic clinical strains. MATERIALS AND METHODS: genotype was analyzed across these classifications. RESULTS: genotype was the most common, detected in 39.4% (152 strains) of all isolates, with a higher prevalence in non-invasive samples (44.1%, 90 strains). CONCLUSION: genotypes differed between invasive and non-invasive strains, the proportion of bca and rib was substantial. Therefore, Alp protein vaccine containing Rib and Cα antigens is expected to provide protection against prevalent GBS strains in Korea. Additional epidemiological studies on GBS vaginal colonization in pregnant women and invasive neonatal strains are needed to support early neonatal sepsis prevention in these high-risk groups.
Source: Infection and Chemotherapy
DOI: 10.3947/ic.2024.0127
Institutions: Ewha Womans University, Ewha Womans University Medical Center, Ewha Womans University Seoul Hospital, Ewha Womans University Mokdong Hospital, Seoul National University, Seoul National University Bundang Hospital, Jeonbuk National University Hospital, Jeonbuk National University, Hallym University Sacred Heart Hospital
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $200
OpenAlex ID: W4410278764