Work

Acute Toxicities of Bromophenols to Alga and Daphina: Comparative Species Sensitivity Distribution Between Standard and Dietary Supplementation Tests

Year: 2025

Type: article

Abstract: Bromophenols are synthesized chemicals that are widely used in various industrial activities and are also naturally produced by marine algae as secondary metabolites, including 2,4‐dibromophenol (2,4‐DBP), 2,6‐dibromophenol (2,6‐DBP), and 2,4,6‐tribromophenol (2,4,6‐TBP). However, the toxicological profiles and toxicity data of these bromophenols remain largely unreported, necessitating further investigation. Acute toxicity tests of 2,4‐DBP, 2,6‐DBP, and 2,4,6‐TBP were conducted in this study using Scenedesmus quadricauda and Daphnia magna (standard tests). Furthermore, a modified acute toxicity test of D. magna was proposed, which further evaluates the dietary supplementation effects (1.0 × 10 4 cells/mL of S. quadricauda ) on the toxicities of these three bromophenols (modified tests). The median effect concentrations (EC 50 s) of D. magna increased significantly when S. quadricauda was supplied as the dietary supplement. The EC 50 values of 2,4‐DBP increased from 2.17 to 4.47 mg/L, 2,6‐DBP from 2.78 to 6.75 mg/L and 2,4,6‐TBP from 1.57 to 3.28 mg/L. Moreover, the web‐based interspecies correlation estimation platform coupled with the species sensitivity distribution model (Web‐ICE‐SSD) was used to calculate the fifth percentile hazard concentrations (HC 5 s) for 2,4‐DBP, 2,6‐DBP, and 2,4,6‐TBP. The HC 5 values when using standard test data for 2,4‐DBP, 2,6‐DBP, and 2,4,6‐TBP were 0.55, 0.71, and 0.43 mg/L, respectively. In contrast, the HC 5 values when using modified test data increased to 1.20, 1.80, and 0.88 mg/L. These results indicated that dietary supplementation during acute toxicity tests may provide more environment‐related risk assessment.

Source: Journal of Toxicology

DOI: 10.1155/jt/3399746

Authors: Bin Li, Xueling Xiang, Jianghong Shi, Mengtao Zhang, Hui Ge

Institutions: Harbin Institute of Technology, Southern University of Science and Technology

Language: English

Topic: Environmental Toxicology and Ecotoxicology

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,100

Funders: National Natural Science Foundation of China, Natural Science Foundation for Young Scientists of Shanxi Province, Young Scientists Fund