Elimination Percentage and Dose Load from Radioisotope on Critical Organs of Laboratory Animals when using Sorbents
Year: 2025
Type: article
Abstract: One of the most urgent problems of modern medicine and veterinary medicine is the search for effective methods of prevention and nosotropic therapy for radiation damage to humans and animals.The first stage was carried out on 30 laboratory mice.According to hematological studies of animal blood, all blood parameters were within the normal range.The second stage included the evaluation of the effectiveness of sorbents in rats by determining the percentage of radioisotope elimination from the animal body when using the sorbent and determining the dose load from the radioisotope over time (after 5, 15, 30, and 60min) on critical organs (gastrointestinal tract) and its elimination from the rat body.In one group, the rats were monitored without using the sorbent enriched with Shungite and bentonite.In contrast, the other group consisted of rats that received the sorbent with the feed (administered twice with an interval of 8-12 hours).The difference in the accumulation of radiopharmaceutical preparations in the area of interest (gastrointestinal tract) between the two groups was 4.48% after 5min (5min), 1.39% after 15min (20min), 1.35% after 30min (50min), and 1.04% after 60min (110min).The study revealed significantly higher initial RPP accumulation in the GI tract of the first group (4.48% at 5min), with differences gradually decreasing to 1.04% by 60min, suggesting variations in absorption/metabolism between groups.Shungite-enriched bentonite demonstrated high efficacy as a radioprotective sorbent, reducing radionuclide-induced damage when administered twice at 8-12-hour intervals and maintaining chemical stability.Its use enhanced adaptive regulatory mechanisms for accelerated radionuclide elimination, lowering risks of radiation-induced pathologies.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4410280622