Work

A chiral metal–organic framework fluorescent sensor incorporating H 8 -BINOL

Year: 2025

Type: article

Abstract: Fluorescent chiral chemical sensors with high enantioselectivity enable the identification of enantiomers in an inexpensive, accessible, and rapid manner even at low analyte concentrations. The discrimination of enantiomeric systems is of high importance in pharmaceutical and health sciences due to potential deleterious side effects of specific enantiomers and the potential for disease detection. In this work, the first metal-organic frameworks (MOFs) containing H8-BINOL showed impressive enantioselective ratios (ERs) of 8.95 and 11.33 toward aspartic acid dimethyl ester exhibiting unique non-inverted enantioselectivity. The fluorescence behaviour with amino acids and their derivatives are examined with consideration of amino acid side chains, polarity, and intermolecular interactions. We demonstrate that the incorporation of additional steric hindrance with axial chirality is a powerful strategy for enhancing enantioselectivity in fluorescent chiral chemical sensors.

Source: Materials Chemistry Frontiers

DOI: 10.1039/d5qm00277j

Authors: Pattara Siripanich, Jierui Zhang, Martina Lessio, Carol Hua

Institutions: The University of Melbourne, UNSW Sydney

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Centre of Excellence in Exciton Science

Award: G5165007477