Work

Hyaluronic acid-loaded drug-eluting nanofibrous pad for the treatment of degenerative arthritis

Year: 2025

Type: article

Abstract: , the drug-eluting nanofibrous pad sustained the release of teicoplanin, ceftazidime, and ketorolac for 10, 24, and 30 days, respectively, and maintained high levels of connective tissue growth factor elution over a 30-day period. Moreover, animal testing demonstrated that the pad released significant amounts of antimicrobial and pain-relieving agents in a rabbit knee joint model for over 28 days. Rabbits implanted with the drug-eluting pads exhibited activity levels comparable to those that did not undergo surgery. These findings indicate that the hyaluronic acid-loaded, drug-eluting nanofibrous degradable pad, with its extended release of pharmaceuticals and biomolecules, may be used for the treatment of degenerative arthritis.

Source: RSC Advances

DOI: 10.1039/d5ra01494h

Authors: Yung-Heng Hsu, Pin-Chao Feng, Yi-Hsun Yu, Ying-Chao Chou, Zhe-Pei Wang, Shih-Jung Liu

Institutions: Chang Gung Memorial Hospital, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan Chang Gung Memorial Hospital

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042