Multi-View Transformers for Airway-to-Lung Ratio Inference on Cardiac CT Scans: The C4R Study
Year: 2025
Type: conference-paper
Abstract: The ratio of airway tree lumen to lung size (ALR), assessed at full inspiration on high resolution full-lung computed tomography (CT), is a major risk factor for chronic obstructive pulmonary disease (COPD). There is growing interest to infer ALR from cardiac CT images, which are widely available in epidemiological cohorts, to investigate the relationship of ALR to severe COVID-19 and post-acute sequelae of SARS-CoV-2 infection (PASC). Previously, cardiac scans included approximately 2/3 of the total lung volume with 5-6x greater slice thickness than high-resolution (HR) full-lung (FL) CT. In this study, we present a novel attention-based Multi-view Swin Transformer to infer FL ALR values from segmented cardiac CT scans. For the supervised training we exploit paired full-lung and cardiac CTs acquired in the Multi-Ethnic Study of Atherosclerosis (MESA). Our network significantly outperforms a proxy direct ALR inference on segmented cardiac CT scans and achieves accuracy and reproducibility comparable with a scan-rescan reproducibility of the FL ALR ground-truth.
Institutions: Columbia University, University of Iowa
Language: English
Topic: COVID-19 diagnosis using AI
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1261793039, G1269631540, G1276754516, G1294553593, G1412221515, G1539384734, G1640378483, G1803853571, ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating Center, G1983464145, G2095942735, G2144938473, G22458031, G2580996367, G2726417417, G2837638605, G290884426, G291913881, G3093995152, G350785449, G3570589137, G3595232572, G3676546685, G370977179, Novel Quantitative Emphysema Subtypes in MESA and SPIROMICS, G3990748671, G4086764833, G4309390892, G4405402368, G4563812999, G4590187187, G4986157935, G5075046117, G5108002584, G514410172, G5653954166, G5654179670, G5942487649, Institute for Clinical and Translational Research, G66341962, G6742279884, G6798586005, G6856766826, G7055397874, G7166352866, G7462069030, G78770644, Clinical and Translational Science Award, G8145863542, G842756795, G8761005068, G8823037953, G8852914737, Combined Cardiopulmonary Failure in COPD: SPIROMICS HF, G9000004549, G9000004784, G9000006353, G9000017360, G9000019818, G9000025517, G9000026317, G9000038858, G9000063950, G9000065698, G9000234302, G94668252, G991334795
OpenAlex ID: W4410295149