Year: 2025
Type: review
Abstract: Experimental design in the synthetic chemistry community primarily focuses on optimizing reaction conditions by modifying one variable at a time (OVAT). Design of Experiments (DoE) methodology, already commonplace in the chemical industry, captures optimal reaction conditions while shrinking the number of experiments required. Additionally, DoE can provide interaction effects between variables that are not captured in OVAT optimizations. Despite the cost- and time-saving benefits that DoE can provide, it has not been widely adopted by the academic community. This start-up guide is the first entry-level manual, designed for synthetic chemists, with worked examples for the practical implementation of DoE methodology in the context of synthetic method development.
Source: ACS Catalysis
Institution: Iowa State University
Language: English
Field: Decision Sciences
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W4410304486