Research Progress in Asymmetric Synthesis of C2 Chiral Indolin-3-ones Involving 2-Substituted-3H-indol-3-ones
Year: 2025
Type: article
Abstract: Compounds containing 2,2-disubstituted indoline-3-one skeletons are widely used in many fields such as natural products and chiral drugs.The efficient construction of 2,2-disubstituted indolin-3-ones by asymmetric catalysis has attracted more and more attention.The research progress in the asymmetric synthesis of 2,2-disubstituted indolin-3-ones using 2-substituted indolin-3-ones as substrates in recent years is reviewed, including asymmetric aza-Friedel-Crafts reaction, Mannich reaction, aza-Diels-Alder reaction, aza-Henry reaction, aza-Morita-Baylis-Hillman reaction and other reactions.It provides a reference for the future asymmetric synthesis of C2 quaternary carbon center indolin-3-one compounds.
Authors: Xiu-Xiu Qiao, Qian Li, Shi'na Zhao, Ruiqi Wei, Tao Ma, Yong-Hui He, Xiao-Jing Zhao
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4410310055