Year: 2025
Type: conference-paper
Abstract: Objective: Decreased nicotinamide adenine dinucleotide (NAD+) levels are a common feature of cardiovascular diseases, exogenous NAD+ can also block myocardial hypertrophy responses in vivo and in vitro. A few studies have reported the anti-arrhythmic effects of NAD+ and late sodium current (INaL) contributes to the occurrence of arrhythmias, there are currently no reports on the effect of NAD+ on INaL. This study aims to explore whether NAD+ exerts anti-arrhythmic effects by inhibiting INaL. Methods: Whole cell patch clamp technology was applied to investigate the effects of NAD+ on INaL, transient outward potassium current (Ito) in mice ventricular myocytes. The electrocardiograms (ECGs) of the mice was recorded for the anti-arrhythmic effect induced by Anemone toxinⅡ (ATXⅡ, INaL specific opener) of NAD+.
Source: BIO Web of Conferences
Authors: Zhijie Liu, Min Zhang, Antao Luo
Institution: Wuhan University of Science and Technology
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410310056